Cell signaling has been well recognized as a highly complex process, which mainly delivers environmental information into cells. A number of regulating mechanisms of cell signaling have been uncovered in great details. Recently, JMCB also published several articles on new members or regulating mechanisms of various cell signaling pathways (Wu, 2013). In this issue, the collection of four articles will add new aspects to understanding the molecular mechanisms of cell signaling.

It has been revealed that tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) plays an important …